Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice.


The mycotoxin aflatoxin B1 (AFB1) may initiate cancer by causing oxidatively damaged DNA, specifically by causing 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) lesions. Base excision repair removes these lesions, with 8-oxoguanine glycosylase (OGG1) being the rate-limiting enzyme. The aim of this study was to determine the effect of ogg1 deficiency on AFB1… (More)
DOI: 10.1093/mutage/geu087


2 Figures and Tables