Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.

@article{Heilbronn2006EffectO6,
  title={Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.},
  author={Leonie K Heilbronn and Lilian de Jonge and Madlyn I. Frisard and James P DeLany and D. Enette Larson-Meyer and Jennifer Rood and Tuong Nguyen and Corby K. Martin and Julia Volaufova and Marlene M. Most and Frank L Greenway and Steven R. Smith and Walter A. Deutsch and Donald A. Williamson and Eric Ravussin},
  journal={JAMA},
  year={2006},
  volume={295 13},
  pages={1539-48}
}
CONTEXT Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans. OBJECTIVE To examine the effects of 6 months of calorie restriction, with or without exercise, in overweight, nonobese (body mass index, 25 to <30) men and women. DESIGN, SETTING, AND PARTICIPANTS Randomized… CONTINUE READING
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Does food restricCALORIE RESTRICTION, METABOLIC ADAPTATION, AND OXIDATIVE STRESS ©2006 American Medical Association

  • R McCarter, EJ Masoro, BP. Yu
  • All rights reserved
  • 2006

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