Effect of 6-hydroxydopamine (6-OHDA) on proliferation of glial cells in the rat cortex and striatum: evidence for de-differentiation of resident astrocytes

@article{Wachter2010EffectO6,
  title={Effect of 6-hydroxydopamine (6-OHDA) on proliferation of glial cells in the rat cortex and striatum: evidence for de-differentiation of resident astrocytes},
  author={Britta Wachter and Sonja Sch{\"u}rger and Jens Rolinger and Andreas von Ameln-Mayerhofer and Daniela Berg and Hans-Jochen Wagner and Eva Kueppers},
  journal={Cell and Tissue Research},
  year={2010},
  volume={342},
  pages={147-160}
}
Reactive astrogliosis is the universal response to any brain insult. It is characterized by cellular hypertrophy, up-regulation of the astrocyte marker glial fibrillary acidic protein (GFAP), and proliferation. The source of these proliferating cells is under intense debate. Progenitor cells derived from the subventricular zone (SVZ), cells positive for chondroitin sulfate proteoglycan (NG2+), and de-differentiated astrocytes have been proposed as the origin of proliferating cells following… CONTINUE READING

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