Effect of 6-azauridine on plasma cell tumors of mice: correlation of antitumor effect with inhibition of orotic acid metabolism.


This investigation was undertaken to correlate the antineoplastic effects of 6-azauridine (AzUR) with the activity of orotic acid metabolism and its inhibition in vitro by AzUR in a series of plasma cell tumors of mice. Although AzUR suppressed tumor growth only moderately and to widely different degrees in different tumors, its antitumor effects in vivo… (More)


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