Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.

@article{Andresen2007EffectO5,
  title={Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.},
  author={Viola Andresen and Michael Camilleri and Irene A Busciglio and April M. B. Grudell and Duane Burton and Sanna McKinzie and Amy Foxx-Orenstein and Caroline B. Kurtz and Vineeta Sharma and Jeffrey M. Johnston and Mark G. Currie and Alan R. Zinsmeister},
  journal={Gastroenterology},
  year={2007},
  volume={133 3},
  pages={761-8}
}
BACKGROUND & AIMS Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and decreases visceral hypersensitivity in animal studies. In healthy volunteers, linaclotide was safe, well tolerated, increased stool frequency, and decreased stool consistency and time to first bowel movement. This randomized… CONTINUE READING