Effect of 5-bromodeoxyuridine on deoxyribonucleic acid-protein adducts induced by ultraviolet light on chromatin cells.

@article{Schiaffonati1978EffectO5,
  title={Effect of 5-bromodeoxyuridine on deoxyribonucleic acid-protein adducts induced by ultraviolet light on chromatin cells.},
  author={Luisa Schiaffonati and Yoshihiro Tsutsui and Sung Dong Chang and Renato Baserga},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1978},
  volume={38 1},
  pages={58-66}
}
The formation of DNA-protein adducts induced by ultraviolet irradiation (254-nm. wavelength) has been analyzed by cesium chloride equilibrium sedimentation. The formation of ultraviolet-induced DNA-protein adducts is increased in 5-bromodeoxyuridine-substituted chromatin. Cross-linking is dependent in part upon the extent of 5-bromodeoxyuridine substitution, and is detectable either in chromatin irradiated in vitro or in chromatin from cells irradiated in vivo prior to the isolation of… CONTINUE READING