Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat

@article{Gasbarri2008EffectO5,
  title={Effect of 5-HT7 antagonist SB-269970 in the modulation of working and reference memory in the rat},
  author={Antonella Gasbarri and Agata Cifariello and Assunta Pompili and Alfredo Meneses},
  journal={Behavioural Brain Research},
  year={2008},
  volume={195},
  pages={164-170}
}
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References

SHOWING 1-10 OF 90 REFERENCES

Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task

  • A. Meneses
  • Psychology, Biology
    Behavioural Brain Research
  • 2004

5-HT1A receptors and memory

Do serotonin(1-7) receptors modulate short and long-term memory?

  • A. Meneses
  • Biology, Psychology
    Neurobiology of learning and memory
  • 2007
Analysis of the contribution of 5-HT, cholinergic and glutamatergic receptors as well as protein synthesis to STM and LTM of an autoshaping learning task indicates that '5-HT tone via 5- HT(1B) receptors' might function in a serial manner from STM to LTM, whereas working in parallel using 5-hydroxytryptamine receptors.

Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task

Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats.

5-HT4 Receptors Improve Social Olfactory Memory in the Rat

Do serotonin1–7 receptors modulate short and long-term memory?

  • A. Meneses
  • Biology, Psychology
    Neurobiology of Learning and Memory
  • 2007

A pharmacological analysis of an associative learning task: 5-HT(1) to 5-HT(7) receptor subtypes function on a pavlovian/instrumental autoshaped memory.

  • A. Meneses
  • Biology, Psychology
    Learning & memory
  • 2003
Results indicate that pharmacological manipulation of 5-HT1-7 receptors or5-HT reuptake sites might modulate memory consolidation, which is consistent with the emerging notion that 5- HT plays a key role in memory formation.

Role of serotonin in memory impairment

Converging evidence suggests that the administration of 5-HT2A/2C or 5- HT4 receptor agonists or5-HT1A or 5HT3 and 5-ht1B receptor antagonists prevents memory impairment and facilitates learning in situations involving a high cognitive demand.

5-HT1A receptor expression during memory formation

These data suggest that upregulated, downregulated, and “silence” of 5-HT1A receptors in brain areas form part of neural circuits engaged in memory formation by demonstrating a high degree of specificity and memory mapping.
...