Effect of 5-HT5A antagonists in animal models of schizophrenia, anxiety and depression

@article{Kassai2012EffectO5,
  title={Effect of 5-HT5A antagonists in animal models of schizophrenia, anxiety and depression},
  author={Ferenc Kassai and Chantal Schlumberger and Rita Kedves and Małgorzata Pietraszek and Claudia Jatzke and Bal{\'a}zs Lendvai and István Gyertyán and Wojciech Danysz},
  journal={Behavioural Pharmacology},
  year={2012},
  volume={23},
  pages={397–406}
}
The few available data on the pharmacological effect of 5-HT5A receptors suggest that antagonists may have anxiolytic, antidepressant and antipsychotic activity. The aim of our study was to verify these suggestions in relevant animal models. Two 5-HT5A antagonist ligands, SB-699551-A (N-[2-(dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride) (3–60 mg/kg, intraperitoneally) and A-843277 (N-(2,6-dimethoxybenzyl)-N′[4-(4… Expand
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