Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells.

@article{Larini2004EffectO4,
  title={Effect of 4-hydroxynonenal on antioxidant capacity and apoptosis induction in Jurkat T cells.},
  author={Alessandra Larini and Laura Bianchi and Velio Bocci},
  journal={Free radical research},
  year={2004},
  volume={38 5},
  pages={509-16}
}
4-Hydroxynonenal (HNE) is one of the major end products of lipid peroxidation and may have either physiological or pathological significance regulating cell proliferation. We studied some biochemical effects of HNE, at various concentrations (0.1-100 microM), on Jurkat T cells incubated thereafter for 24, 48 and 72 h. HNE at low concentrations significantly enhanced the proliferation index, whereas at higher concentrations progressively blocked cell proliferation. Caspase 3 activity increased… CONTINUE READING