Effect of 4-(12-Dihydroartemisininoxy) Benzoic Acid hydrazide Transferrin Tagged Drug on Human Breast Cancer Cells

@inproceedings{Xie2009EffectO4,
  title={Effect of 4-(12-Dihydroartemisininoxy) Benzoic Acid hydrazide Transferrin Tagged Drug on Human Breast Cancer Cells},
  author={Wei-Ling Xie and Pei-Hui Yang and Xin Zeng and Ji-Ye Cai},
  year={2009}
}
Abstract As target-carrier, holotransferrin (Tf) was conjugated with dihydroartemisinin (DHA) to form a new targeted drug. An analog of DHA, 4-(12-dihydroartemisininoxy) benzoic acid hydrazide (DBAH) have been synthesized and characterized by UV/vis spectroscopy, IR spectroscopy, NMR, and electrochemistry. Periodate was used to oxidize hydroxy groups on the N-glycoside chains of C-domain on Tf surface, and then DBAH reacted with the oxidized Tf to form a covalent conjugate. In addition, this… CONTINUE READING