Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study

@article{Ngondi2006EffectO3,
  title={Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study},
  author={Jeremiah Ngondi and Alice Onsarigo and Fiona E. Matthews and Mark Reacher and Carol Brayne and Samson P Baba and Anthony W Solomon and James A Zingeser and Paul M Emerson},
  journal={The Lancet},
  year={2006},
  volume={368},
  pages={589-595}
}
Associations between Active Trachoma and Community Intervention with Antibiotics, Facial Cleanliness, and Environmental Improvement (A,F,E)
TLDR
Analysis of associations between the A,F,E components of the SAFE strategy and active trachoma showed independent protective effects against activetrachoma of mass systemic azithromycin treatment, facial cleanliness, face washing, and use of pit latrines in the household.
Effects of intervention with the SAFE strategy on trachoma across Ethiopia
TLDR
Considerable decline in the magnitude of trachoma and its risk factors was observed in areas where the SAFE strategy was implemented, and the coverage of services should be maintained or improved in order to eliminate blindingtrachoma by the year 2020.
A Systematic Review Examining the Added Value of Water, Sanitation, and Hygiene Interventions for Preventive Chemotherapy Programs on Reducing the Prevalence of Trachoma
TLDR
This review examined the benefits of the added value of water, sanitation, and hygiene education interventions on preventive mass drug administration for trachoma and found the ‘F’ and ‘E’ components provide significant value to the overall decrease of prevalence of activetrachoma.
Risk of trachoma in a SAFE intervention area
TLDR
Provision of SAFE services with high coverage should be sustained in trachoma-hyperendemic areas because elderlyly illiterate women remain at risk of becoming blind from trichiasis even in intervention areas.
Mass Antibiotic Treatment Alone Does Not Eliminate Ocular Chlamydial Infection
TLDR
This paper presents an excellent 42-month longitudinal assessment of ocular Chlamydia infection following four biannual mass treatments in Gurage zone of Southern Nations Nationalities and Peoples Region, a trachoma hyper-endemic area of Ethiopia.
Strategies to Control Trachoma
TLDR
The promotion of facial cleanliness through education may be the key to trachoma elimination as it will stop the frequent exchange of infected ocular secretions and thus reduce the transmission of infection.
The Cochrane Library and trachoma: an overview of reviews
TLDR
There are no clinical trials of the full SAFE strategy for trachoma control on blindness prevention, or on reducing activetrachoma, or ocular Chlamydia trachomatis infection, but there is some evidence that separately supports each of the components of SAFE: surgery, antibiotics, facial cleanliness, and environmental improvements.
A close look at trachoma control and the challenges that district programs pose
TLDR
The district is the implementation unit of the control strategy, and this poses unique challenges for a disease program because it is largely not based on ‘case finding’ but implementation of an intervention at a population level.
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