Corpus ID: 28301634

Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.

@article{Welch1976EffectO3,
  title={Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.},
  author={R. Welch and C. Hughes and R. Deangelis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1976},
  volume={4 4},
  pages={
          402-6
        }
}
A thin-layer chromatographic procedure is described for the quantitative determination of phenacetin and acetaminophen in rat plasma. The method was used to determine the effect of 3-methylcholanthrene (3-MC) on the disposition and bioavailability of phenacetin following its oral and iv administration to rats. Pretreatment with 3-MC decreased the plasma half-life of phenacetin, after iv administration, from 28 min to 4.5 min and reduced the systemic bioavailability of phenacetin, after oral… Expand
Disposition of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
TLDR
The response to oral and intraperitoneal pretreatment with 3,4-benzpyrene appears to be profoundly different, and a technique for selective enzyme induction in the intestine by the route of administration of inducer is discussed. Expand
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats.
TLDR
It is indicated that after pretreatment with various enzyme inducers the phenacetin-induced hepatic GSH depletion strongly correlates with microsomal Phenacetin O-deethylation, and a discrepancy between 4,4'-DCB and PB in cytochrome P-450 inducing activity is suggested. Expand
Phenacetin O-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds.
TLDR
There is no major difference between the DA and Fischer strains in their ability to O-deethylate phenacetin, thus, unlike poor metabolizers of debrisoquine in the human population, the DA rat is deficient in only the former activity. Expand
Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo
TLDR
Findings improve the understanding of CYP-mediated drug interactions with M. officinalis and its active constituents and could at least be partly attributed to their lower IC50 values for the inhibition of phenacetin metabolism than for diclofenac metabolism. Expand
Gastrointestinal and hepatic first‐pass metabolism of aspirin in rats
TLDR
The first‐pass effect of aspirin was measured in male Wistar rats by comparing the plasma concentration after intravenous, oral or intraportal administration (10 mg kg−1) of the drug, and it is suggested that the gastrointestinal absorption of aspirinwas essentially complete in rats. Expand
Effect of Aroclor 1254, phenobarbital, and polycyclic aromatic hydrocarbons on the plasma clearance of caffeine in the rat
TLDR
The above studies indicate that the plasma clearance of caffeine is markedly increased in rats pretreated with phenobarbital, PCH, or Aroclor 1254 and suggest that the metabolism and pharmacology of caffeine may be considerably altered in human subjects exposed to these substances. Expand
The use of stable isotopes to better define toxic metabolic pathways of p-hydroxyacetanilide (acetaminophen) and p-ethoxyacetanilide (phenacetin)
Phenacetin (acetophenetidine) is a minor analgesic which has been associated with various toxic effects, including methaemoglobinaemia and haemolysis (Beutler, 1969) and renal damage (Abel, 1970).Expand
Analgesie drugs in breast milk and plasma *
The disposition of salicylic acid, phenacetin, caffeine, and codeine, and two metabolites, acetaminophen and morphine, was studied in breast milk and plasma of two lactating mothers after single oralExpand
Nutrition and chemical biotransformations in man
TLDR
Nutritional factors are important in the regulation of drug metabolism in animals and in man and feeding charcoal‐broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver, suggesting marked individuality in the responsiveness of different people to changes in the diet. Expand
Excretion of drugs in human breast milk.
TLDR
It is projected, from estimated steady-state milk concentrations of the drugs and their metabolites studied, that very low percentages of the therapeutic dosages would be excreted in mother's milk, too low an amount to be clinically significant to the infant. Expand
...
1
2
3
...