Corpus ID: 28301634

Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.

  title={Effect of 3-methylcholanthrene pretreatment on the bioavailability of phenacetin in the rat.},
  author={R. Welch and C. Hughes and R. Deangelis},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={4 4},
A thin-layer chromatographic procedure is described for the quantitative determination of phenacetin and acetaminophen in rat plasma. The method was used to determine the effect of 3-methylcholanthrene (3-MC) on the disposition and bioavailability of phenacetin following its oral and iv administration to rats. Pretreatment with 3-MC decreased the plasma half-life of phenacetin, after iv administration, from 28 min to 4.5 min and reduced the systemic bioavailability of phenacetin, after oral… Expand
Disposition of phenacetin in rabbits pretreated orally and intraperitoneally with 3,4-benzpyrene.
The response to oral and intraperitoneal pretreatment with 3,4-benzpyrene appears to be profoundly different, and a technique for selective enzyme induction in the intestine by the route of administration of inducer is discussed. Expand
The 3-methylcholanthrene-mimetic effect of 4,4'-dichlorobiphenyl-treatment on phenacetin-induced hepatic glutathione depletion and liver microsomal phenacetin O-deethylation in rats.
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The disposition of salicylic acid, phenacetin, caffeine, and codeine, and two metabolites, acetaminophen and morphine, was studied in breast milk and plasma of two lactating mothers after single oralExpand
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Nutritional factors are important in the regulation of drug metabolism in animals and in man and feeding charcoal‐broiled beef enhances the metabolism of phenacetin in the gastrointestinal tract and/or during its first pass through the liver, suggesting marked individuality in the responsiveness of different people to changes in the diet. Expand
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