Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: a prospective study.

@article{Somma2003EffectO2,
  title={Effect of 2 years of cortisol normalization on the impaired bone mass and turnover in adolescent and adult patients with Cushing's disease: a prospective study.},
  author={Carolina Di Somma and Rosario Pivonello and Sandro Loche and Antongiulio Faggiano and Michele Klain and Marco Salvatore and Gaetano Lombardi and Annamaria Colao},
  journal={Clinical endocrinology},
  year={2003},
  volume={58 3},
  pages={302-8}
}
BACKGROUND Osteoporosis is a frequent, severe and often underestimated consequence of long-term hypercortisolism, often presenting as bone fracture. OBJECTIVE This prospective study was designed to evaluate whether the abnormalities of bone mass and turnover can be similarly reversed in adolescent and adult patients with Cushing's disease, after correction of hypercortisolism. PATIENTS AND METHODS Bone mineral density (BMD) at lumbar spine, serum osteocalcin (OC) and urinary cross-linked N… CONTINUE READING