Effect of 2-4-dinitrophenol on intercellular communication in mammalian cardiac fibres.

@article{Mello1979EffectO2,
  title={Effect of 2-4-dinitrophenol on intercellular communication in mammalian cardiac fibres.},
  author={Walmor C. De Mello},
  journal={Pflugers Archiv : European journal of physiology},
  year={1979},
  volume={380 3},
  pages={267-76}
}
The effect of 2-4-dinitrophenol (DNP) on cell communication, in canine Purkinje fibres, was investigated. It was found that DNP (0.5 MM) suppressed the electrical coupling in about 10 min. This effect of DNP was largely due to an increment in intracellular longitudinal resistance. The longitudinal movement of fluorescein (mol. wt. 320) along Purkinje strands, followed with the cut-end method, was also suppressed by DNP (0.5 mM). The decoupling action of DNP was related to release of Ca from… CONTINUE READING

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