Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.

  title={Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain.},
  author={Shaorui Chen and Krystyna M. Wozniak and Barbara S. Slusher and Hui-Lin Pan},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={300 2},
  • Shaorui ChenK. Wozniak H. Pan
  • Published 1 February 2002
  • Biology, Medicine
  • The Journal of pharmacology and experimental therapeutics
Increased glutamate availability in the spinal cord and primary afferent nerves plays an important role in acute and chronic pain. Afferent ectopic discharges from the site of nerve injury constitute a source of abnormal sensory input to the spinal dorsal horn. The ectopic afferent activity is largely responsible for the development of hypersensitivity of dorsal horn neurons and neuropathic pain. Inhibition of glutamate carboxypeptidase II (GCP II) reduces glutamate release generated from N… 

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