Effect of 2,3-butanedione 2-monoxime on slow inward and transient outward currents in rat ventricular myocytes.

@article{Coulombe1990EffectO2,
  title={Effect of 2,3-butanedione 2-monoxime on slow inward and transient outward currents in rat ventricular myocytes.},
  author={Alain Coulombe and Isabel Ann Lef{\`e}vre and Edith Deroubaix and Dominique Thuringer and Edouard Coraboeuf},
  journal={Journal of molecular and cellular cardiology},
  year={1990},
  volume={22 8},
  pages={921-32}
}
The effect of 2,3-butanedione 2-monoxime (BDM), a substance possessing phosphatase-like activity, was studied on action potentials of isolated rat heart and on the slow inward calcium current and outward current (including the 4-aminopyridine (4-AP)-sensitive transient outward component), in rat ventricular myocytes. In contrast to what was observed by other authors in different species and cardiac tissues, BDM increased markedly the amplitude and duration of the rat ventricular action… CONTINUE READING

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