Effect of 1918 PB1-F2 Expression on Influenza A Virus Infection Kinetics

@inproceedings{Smith2011EffectO1,
  title={Effect of 1918 PB1-F2 Expression on Influenza A Virus Infection Kinetics},
  author={Amber M. Smith and Frederick R. Adler and Julie L. McAuley and Ryan N. Gutenkunst and Ruy M. Ribeiro and Jonathan A. McCullers and Alan S. Perelson},
  booktitle={PLoS Computational Biology},
  year={2011}
}
Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral polymerase activity in vitro, enhances inflammation and increases secondary pneumonia in vivo. However, the effects the PB1-F2 protein have in vivo remain unclear. To address the mechanisms involved… CONTINUE READING