Effect of 17beta-estradiol on apoptosis, IGF system components and gelatinases A and B in prostate cancer cells (PC-3).

@article{Kanagaraj2007EffectO1,
  title={Effect of 17beta-estradiol on apoptosis, IGF system components and gelatinases A and B in prostate cancer cells (PC-3).},
  author={Palaniyandi Kanagaraj and Marati Radhakrishnan Vijayababu and Ramachandran Ilangovan and Kalimuthu Senthilkumar and Preeti Venkataraman and Maria Michael Aruldhas and Jagadeesan Arunakaran},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2007},
  volume={377 1-2},
  pages={70-8}
}
BACKGROUND Previous studies have indicated that estrogen administration in the advanced stage of prostate cancer provide some benefits to the patients. Estrogen action was thought to be mediated via the blockade of the pituitary-testicular axis that effectively lowered the circulating levels of androgen and, thus, results in tumor regression; however, the effect of estrogens on prostate epithelial cells is still unclear. We investigated the effects of estradiol on insulin-like growth factor… CONTINUE READING