Effect of 17-beta-estradiol on dopamine, serotonine and GABA striatal levels in 6-hydroxydopamine-treated rats.

Abstract

Intrastriatal injection (16microg) of the neurotoxic dopaminergic agent 6-hydroxydopamine (6-OHDA) in ovariectomized rats caused important reductions in striatal dopamine (DA) and serotonin (5-HT) levels and an increase in GABA content. Treatment of ovariectomized rats with estradiol (5 mg 17-beta-estradiol administered by a subcutaneous cannula) before 6-OHDA injection maintained the control levels of these neurotransmitters. The administration of estradiol after 6-OHDA injection did not lead to their recovery. These findings suggest that estradiol acts as a neuroprotectant--but not as a neuroreparatory agent--and that it might be able to attenuate striatal dopaminergic neuron degeneration caused by neurotoxic agents.

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@article{Peinado2004EffectO1, title={Effect of 17-beta-estradiol on dopamine, serotonine and GABA striatal levels in 6-hydroxydopamine-treated rats.}, author={Virginia Peinado and Jos{\'e} Carlos Gonz{\'a}lez and Mar{\'i}a Luisa Leret}, journal={Toxicology}, year={2004}, volume={204 2-3}, pages={155-60} }