Effect of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on the healing of duodenal ulcer: a double-blind multicenter study.

@article{Vantrappen1982EffectO1,
  title={Effect of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on the healing of duodenal ulcer: a double-blind multicenter study.},
  author={Gaston R. Vantrappen and Jozef Janssens and Tadeusz J. Popiela and Jan Kulig and Guido N. J. Tytgat and Kees Huibregtse and R. F. Lambert and J P Pauchard and A. Kratzke Robert},
  journal={Gastroenterology},
  year={1982},
  volume={83 2},
  pages={357-63}
}
A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostaglandin E2 (arbaprostil) (82 patients). Each drug was ingested four times a day (1 h before meals and at bedtime) for 28 days. Endoscopy was performed on days 0, 14, and 28 after… CONTINUE READING
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