Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.

@article{Sadanobu1997EffectO1,
  title={Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.},
  author={S Sadanobu and Makoto Takeuchi and Masakatsu Tezuka},
  journal={The Journal of toxicological sciences},
  year={1997},
  volume={22 5},
  pages={
          413-26
        }
}
The protective effect of 1,3-dithia-2-thioxo-cyclopent-4-ene (DT827A) and its two derivatives of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene (DT827B) and 4-(4-fluorophenyl)-1,3-dithia-2-thioxo-cyclopent-4-ene (DT827C) on liver injury induced by carbon tetrachloride (CCl4) and orotic acid was studied using male rats. The approximate lethal doses were about 100 mg/kg for DT827A-treated animals and more than 800 mg/kg for the other two compounds-treated groups. Single oral administration of the… 
3 Citations
Effect of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene on liver injury induced by repeated exposure to galactosamine plus carbon tetrachloride in rats.
TLDR
A hepatoprotective potential of DT827B was suggested under the conditions of these studies after a therapeutic effect against liver injury induced by D-GalN + CCl4 dose-dependently was suggested.
In vitro tests of 1,3-dithia-2-thioxo-cyclopent-4-ene to evaluate the mechanisms of its hepatoprotective action.
TLDR
The protective effect of DT827A on a liver injury is due neither to its influence on liver GSH levels nor inhibition of the metabolic activation of CCl4, but a possible mechanism of action for theDT827 series of compounds to indicate an antioxidative effect would be brought about by the role of the compounds as a radical scavenger as well as its reductive effect.
Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
TLDR
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene was examined in reverse mutation tests, in the chromosomal aberration test with Chinese hamster ovary cells, and in the micronucleus test using mice bone-marrow, finding the increase in polyploidy probably is due to a toxic effect of the compound.

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