Effect of 1,24R‐dihydroxyvitamin D3 on the Growth of Human Keratinocytes
@article{Matsumoto1990EffectO1, title={Effect of 1,24R‐dihydroxyvitamin D3 on the Growth of Human Keratinocytes}, author={K. Matsumoto and Koji Hashimoto and Mamoru Kiyoki and M. Yamamoto and Kunihiko Yoshikawa}, journal={The Journal of Dermatology}, year={1990}, volume={17} }
The effect of 1,24R‐dihydroxyvitamin D3 (1,24R(OH)2D3), a synthetic analogue of a biologically active form of vitamin D3 (1,25‐dihydroxyvitamin D3, 1,25(OH)2D3), on the growth of human keratinocytes cultured in serum‐free medium was investigated. The growth of cultured normal human keratinocytes was inhibited by 65% by 10−8M 1,24R(OH)2D3 and by 90% by 10−7M 1,24(OH)2D3. It inhibited cell growth almost completely at 10−6M. The DNA synthesis of keratinocytes was also inhibited with 1,24R(OH)2D3…
60 Citations
1α,24R‐Dihydroxyvitamin D3 Has an Ability Comparable to That of 1α,25‐Dihydroxyvitamin D3 to Induce Keratinocyte Differentiation
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BE was significantly more potent than an equivalent concentration of Vit-D in inhibiting growth and survival of human keratinocytes and the antimitotic effect was found to be due to the inhibition of phosphorylation of serine/threonine protein kinase (AKT) and its downstream target, mammalian target of rapamycin (mTOR).
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