Effect of 2,2-bis(Parachlorophenyl)-l,l-Dichloroethane (DDD) on the Adrenal Cortex of the Rat

@article{Stoner1953EffectO2,
  title={Effect of 2,2-bis(Parachlorophenyl)-l,l-Dichloroethane (DDD) on the Adrenal Cortex of the Rat},
  author={H. B. Stoner},
  journal={Nature},
  year={1953},
  volume={172},
  pages={1044-1045}
}
  • H. B. Stoner
  • Published 5 December 1953
  • Chemistry, Medicine
  • Nature
WHILE DDD has been repeatedly shown to produce selective degeneration of the zona fasciculata of the adrenal cortex in the dog1 when fed in daily doses of 50 mgm./kgm., no such effect has been found in rats receiving as much as 2,500 p.p.m. of the drug in the diet2. Physiological changes have been described in rats fed 1,000 p.p.m. DDD which have been attributed to adrenal cortical dysfunction3, and histological damage has been reported after the injection of about 5 gm. over a period of 4–6… 
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References

SHOWING 1-3 OF 3 REFERENCES
Influence of the Drug DDD on Adrenal Cortical Function in Adult Rats.∗ †
  • J. Brown
  • Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1953
Summary Adult rats fed the drug DDD rapidly develop signs of some adrenal dysfunction; decreased eosinophil response, decreased uric acid/creatinine ratio, increased insulin sensitivity and decreased