Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage

@article{Ottani2003EffectO,
  title={Effect of $\gamma$-hydroxybutyrate in two rat models of focal cerebral damage},
  author={Alessandra Ottani and Sabrina Saltini and Marta Bartiromo and Davide Zaffe and Annibale Renzo Botticelli and Anna Ferrari and Alfio Bertolini and Susanna Genedani},
  journal={Brain Research},
  year={2003},
  volume={986},
  pages={181-190}
}

Gamma-Hydroxybutyrate Accelerates Functional Recovery after Focal Cerebral Ischemia

GHB at a low dose accelerates neurological recovery following ischemic stroke and influences ischemia-induced brain injury, as revealed by cresyl violet and neuronal staining.

Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats.

The results show for the first time that the repeated administration of GHB, especially at very low doses, produces neurotoxic effects, which is very relevant because its abuse, especially by young persons, could produce considerable neurological alterations after prolonged abuse.

A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex.

It is demonstrated that a single acute anesthetic dose of 1 g/kg GHB alters a large number of genes, 121 in hippocampus and 53 in prefrontal cortex; 16 genes were modified simultaneously in both brain regions by using DNA microarray studies.

γ-Hydroxybutyric Acid

Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABAB receptor-mediated mechanisms.

Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke

  • A. OttaniD. Giuliani S. Guarini
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
The data support the hypothesis that a protective, melanocortin-activated, vagal cholinergic pathway is likely operative in conditions of ischemic stroke and show that focal brain ischemia in rats causes significant effects not only in the brain, but also in the liver.

Gamma-hydroxybutyric acid: neurobiology and toxicology of a recreational drug.

Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABA(B) receptor-mediated mechanisms.

References

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γ‐Hydroxybutyrate: Cerebral Metabolic, Vascular, and Protective Effects

The cerebral protection afforded by each of several preparations of γ‐hydroxybutyrate (GHB) was examined in the hypoxic mouse model and brain biopsies taken after the cumulative dose of GHB 1100 mg/kg showed a trend toward lower phosphocreatine levels and higher lactate and lactate/pyruvate levels than in untreated dogs.

Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat

The results indicate that ET-1 injected in the neostriatum may produce lesions by causing local ischemia, related to its vasoconstrictor activity and possibly also to an activation ofET-1 receptors in the astroglial-endothelial complex.

Neuroprotective effect of dapsone against quinolinate- and kainate-induced striatal neurotoxicities in rats.

Findings provide evidences to suggest that dapsone is acting as a neuroprotective agent against excitotoxicity induced by glutamate receptor agonists.

EFFECTS OF γ‐BUTYROLACTONE ON LOCAL CEREBRAL GLUCOSE UTILIZATION IN THE RAT

It is suggested that γ‐butyrolactone profoundly depresses cerebral energy metabolism throughout the brain and that it might prove useful in clinical conditions in which a temporary reversible reduction in cerebral energy demand is desired.

Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat

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  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 1993
It is suggested that perivascular microapplication of Et-1 may provide a useful model for the study of the functional disturbances associated with focal cerebral ischaemia in the conscious rat.
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