• DOI:10.1016/S0006-8993(03)03252-9
Corpus ID: 54374774

Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage

@article{Ottani2003EffectO,
  title={Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage},
  author={A. Ottani and S. Saltini and M. Bartiromo and D. Zaffe and S. Genedani},
  journal={Brain Research},
  year={2003},
  volume={986},
  pages={181-190}
}

A. Ottani, S. Saltini, +2 authors S. Genedani

Published 2003

Medicine

Brain Research

Abstract γ-Hydroxybutyrate (GHB) and its lactone, γ-butyrolactone (GBL) have been previously shown to produce a protective effect in animal models of cerebral ischaemia/hypoxia, as well as in human conditions of head injury-induced coma. The aim of the present research was to study the effect of GHB in experimental conditions of focal cerebral damage, either induced by ischaemia or excitotoxicity. Under general anaesthesia, rats were injected into the right striatum with either endothelin-1 (ET… CONTINUE READING

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