Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage

@article{Ottani2003EffectO,
  title={Effect of $\gamma$-hydroxybutyrate in two rat models of focal cerebral damage},
  author={Alessandra Ottani and Sabrina Saltini and Marta Bartiromo and Davide Zaffe and Annibale Renzo Botticelli and Anna Ferrari and Alfio Bertolini and Susanna Genedani},
  journal={Brain Research},
  year={2003},
  volume={986},
  pages={181-190}
}
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46 Citations
Background Citations
14
Methods Citations
2
Results Citations
2

46 Citations

Gamma-Hydroxybutyrate Accelerates Functional Recovery after Focal Cerebral Ischemia

GHB at a low dose accelerates neurological recovery following ischemic stroke and influences ischemia-induced brain injury, as revealed by cresyl violet and neuronal staining.

Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats.

The results show for the first time that the repeated administration of GHB, especially at very low doses, produces neurotoxic effects, which is very relevant because its abuse, especially by young persons, could produce considerable neurological alterations after prolonged abuse.

γ‐Hydroxybutyrate (GHB), γ‐Butyrolactone (GBL), and 1,4‐Butanediol (1,4‐BD) Reduce the Volume of Cerebral Infarction in Rodent Transient Middle Cerebral Artery Occlusion

It is concluded that GHB, GBL, and 1,4‐BD protect against rat focal cerebral ischemia from transient MCAO.

Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.

A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex.

It is demonstrated that a single acute anesthetic dose of 1 g/kg GHB alters a large number of genes, 121 in hippocampus and 53 in prefrontal cortex; 16 genes were modified simultaneously in both brain regions by using DNA microarray studies.

γ-Hydroxybutyric Acid

Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABAB receptor-mediated mechanisms.

Vagus Nerve Mediates the Protective Effects of Melanocortins against Cerebral and Systemic Damage after Ischemic Stroke

  • A. OttaniD. Giuliani S. Guarini
  • Biology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2009
The data support the hypothesis that a protective, melanocortin-activated, vagal cholinergic pathway is likely operative in conditions of ischemic stroke and show that focal brain ischemia in rats causes significant effects not only in the brain, but also in the liver.

Gamma-hydroxybutyric acid: neurobiology and toxicology of a recreational drug.

Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABA(B) receptor-mediated mechanisms.

Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.

Size-controllable striatal lesion model for evaluation of neuroprotective agents in rats

References

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γ‐Hydroxybutyrate: Cerebral Metabolic, Vascular, and Protective Effects

The cerebral protection afforded by each of several preparations of γ‐hydroxybutyrate (GHB) was examined in the hypoxic mouse model and brain biopsies taken after the cumulative dose of GHB 1100 mg/kg showed a trend toward lower phosphocreatine levels and higher lactate and lactate/pyruvate levels than in untreated dogs.

Significance of γ-hydroxybutyric acid in the brain

Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat

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THE γ-HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS

The protective effect of γ-hydroxybutyrate in regional intestinal ischemia in the hamster

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