Effect of γ-hydroxybutyrate in two rat models of focal cerebral damage
@article{Ottani2003EffectO, title={Effect of $\gamma$-hydroxybutyrate in two rat models of focal cerebral damage}, author={Alessandra Ottani and Sabrina Saltini and Marta Bartiromo and Davide Zaffe and Annibale Renzo Botticelli and Anna Ferrari and Alfio Bertolini and Susanna Genedani}, journal={Brain Research}, year={2003}, volume={986}, pages={181-190} }
46 Citations
Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats.
- Biology, PsychologyThe international journal of neuropsychopharmacology
- 2009
The results show for the first time that the repeated administration of GHB, especially at very low doses, produces neurotoxic effects, which is very relevant because its abuse, especially by young persons, could produce considerable neurological alterations after prolonged abuse.
γ‐Hydroxybutyrate (GHB), γ‐Butyrolactone (GBL), and 1,4‐Butanediol (1,4‐BD) Reduce the Volume of Cerebral Infarction in Rodent Transient Middle Cerebral Artery Occlusion
- Biology
- 2006
It is concluded that GHB, GBL, and 1,4‐BD protect against rat focal cerebral ischemia from transient MCAO.
Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins.
- BiologyEuropean journal of pharmacology
- 2007
Gamma-hydroxybutyrate (GHB) induces cognitive deficits and affects GABAB receptors and IGF-1 receptors in male rats
- Biology, PsychologyBehavioural Brain Research
- 2014
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose
- PsychologyNeuroscience & Biobehavioral Reviews
- 2012
A single acute pharmacological dose of γ-hydroxybutyrate modifies multiple gene expression patterns in rat hippocampus and frontal cortex.
- BiologyPhysiological genomics
- 2010
It is demonstrated that a single acute anesthetic dose of 1 g/kg GHB alters a large number of genes, 121 in hippocampus and 53 in prefrontal cortex; 16 genes were modified simultaneously in both brain regions by using DNA microarray studies.
γ-Hydroxybutyric Acid
- Biology
- 2004
Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABAB receptor-mediated mechanisms.
Gamma-hydroxybutyric acid: neurobiology and toxicology of a recreational drug.
- BiologyToxicological reviews
- 2004
Investigation of the inborn error of metabolism succinic semialdehyde deficiency and the murine model of this disorder (SSADH knockout mice), in which GHB plays a major role, may help dissect out GHB- and GABA(B) receptor-mediated mechanisms.
Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils.
- Biology, PsychologyEuropean journal of pharmacology
- 2006
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