Effect of β-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture

Abstract

We studied the effects of norepinephrine and β1-adrenoblockers atenolol and metoprolol on the growth of neuritis in organotypic tissue culture of spinal ganglia from 10–12-day chicken embryos. Atenolol (10−4 M) accelerated the growth of neurites in spinal ganglia by 45%, while metoprolol inhibited the growth of the explants almost in all examined concentrations (10−10–10−4 M). Thus, β1-adrenoblockers can produce opposite effects on neurite growth. Both atenolol and metoprolol abolished the neurite-stimulating effect of norepinephrine, probably, because this effect is mediated via β1-adrenoreceptors of spinal ganglia.

DOI: 10.1007/s10517-007-0178-8

2 Figures and Tables

Cite this paper

@article{Penniyainen2007EffectO, title={Effect of β-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture}, author={V. A. Penniyainen and Ekaterina V Lopatina and Vitaly A. Tsyrlin}, journal={Bulletin of Experimental Biology and Medicine}, year={2007}, volume={143}, pages={556-558} }