Effect of atenolol (open bars) and metoprolol (dark bars) on the growth of NSG from 10-12-day chicken embryos. Here and in Fig. 2: *p<0.05 compared to the control
- Yu. A. Zuikov, I. S. Yavelov, O. V. Averkov, Kardiologiya
We studied the effects of norepinephrine and β1-adrenoblockers atenolol and metoprolol on the growth of neuritis in organotypic tissue culture of spinal ganglia from 10–12-day chicken embryos. Atenolol (10−4 M) accelerated the growth of neurites in spinal ganglia by 45%, while metoprolol inhibited the growth of the explants almost in all examined concentrations (10−10–10−4 M). Thus, β1-adrenoblockers can produce opposite effects on neurite growth. Both atenolol and metoprolol abolished the neurite-stimulating effect of norepinephrine, probably, because this effect is mediated via β1-adrenoreceptors of spinal ganglia.