Effect of α-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats.

@article{Ebrahimi2016EffectO,
  title={Effect of α-Hederin on IL-2 and IL-17 mRNA and miRNA-133a Levels in Lungs of Ovalbumin-Sensitized Male Rats.},
  author={Hadi Ebrahimi and Maryam Fallahi and Amir Mahdi Khamaneh and Mohammad Ali Ebrahimi Saadatlou and Saeideh Saadat and Rana Keyhanmanesh},
  journal={Drug development research},
  year={2016},
  volume={77 2},
  pages={
          87-93
        }
}
α-hederin, a saponin that is a major constituent of English Ivy (Hedera helix) is effective in the treatment of asthma. In the present study, the effect of α-hederin on lung tissue pathology and the levels of the inflammatory mediators; IL-2 mRNA, IL-17 mRNA, and MicroRNAs (miRNA)-133a was evaluated in a rat ovalbumin (OVA)-sensitized model of asthma. Rats were divided randomly into control (C), OVA-sensitized (S), OVA-sensitized pretreated with the antioxidant, thymoquinone (3 mg/kg, S + TQ… CONTINUE READING
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