Effect of 'unstirred' water layer in the intestine on the rate and extent of absorption after oral administration.

@article{Chiou1994EffectO,
  title={Effect of 'unstirred' water layer in the intestine on the rate and extent of absorption after oral administration.},
  author={Win L. Chiou},
  journal={Biopharmaceutics & drug disposition},
  year={1994},
  volume={15 8},
  pages={709-17}
}
  • Win L. Chiou
  • Published 1994 in Biopharmaceutics & drug disposition
The presence of an aqueous diffusion layer or 'unstirred' water layer adjacent to the intestinal membrane has long been regarded as a potential barrier for intestinal absorption of compounds. Theoretical analyses were performed in the present study to quantitatively determine the effect of this layer on the rate and extent of absorption of passively absorbed compounds with different membrane absorption half-lives (10 to 300 min) in humans, dogs, rabbits, rats and mice. Diffusion half-lives… CONTINUE READING