Effect in man of aspirin, standard indomethacin, and sustained release indomethacin preparations on gastric bleeding.

@article{Prichard1988EffectIM,
  title={Effect in man of aspirin, standard indomethacin, and sustained release indomethacin preparations on gastric bleeding.},
  author={Peter J. Prichard and T J Poniatowska and J E Willars and Arthur Ravenscroft and Christopher J. Hawkey},
  journal={British journal of clinical pharmacology},
  year={1988},
  volume={26 2},
  pages={
          167-72
        }
}
1. We have compared acute gastric bleeding caused by a new slow release preparation of indomethacin (indomethacin Continus) with that caused by aspirin and other indomethacin preparations. 2. In a randomized crossover study, blood loss into timed gastric aspirates was determined in 20 healthy volunteers after receiving, over 96 h, either placebo, aspirin (600 mg four times daily; 17 doses) indomethacin BP (50 mg three times daily; 13 doses), Indocid-R (75 mg twice daily; 9 doses) or… CONTINUE READING