Effect-based assessment of persistent organic pollutant and pesticide dumpsite using mammalian CALUX reporter cell lines.

@article{Pieterse2015EffectbasedAO,
  title={Effect-based assessment of persistent organic pollutant and pesticide dumpsite using mammalian CALUX reporter cell lines.},
  author={Bart Pieterse and I J C Rijk and Eszter Simon and Barbara M. A. van Vugt-Lussenburg and B F H Fokke and M van der Wijk and Harrie T Besselink and Roland Weber and Bart van der Burg},
  journal={Environmental science and pollution research international},
  year={2015},
  volume={22 19},
  pages={14442-54}
}
A combined chemical and biological analysis of samples from a major obsolete pesticide and persistent organic pollutant (POP) dumpsite in Northern Tajikistan was carried out. The chemical analytical screening focused on a range of prioritized compounds and compounds known to be present locally. Since chemical analytics does not allow measurements of hazards in complex mixtures, we tested the use of a novel effect-based approach using a panel of quantitative high-throughput CALUX reporter assays… CONTINUE READING
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