Effect and mechanism of intermittent myocardial ischemia induced by exercise on coronary collateral formation.

@article{Lu2008EffectAM,
  title={Effect and mechanism of intermittent myocardial ischemia induced by exercise on coronary collateral formation.},
  author={Xiao Cheng Lu and Tao Wu and Peng Huang and Song Lin and Feng Qiu and Xiangbo Meng and Jing Gao and Jian-an Li},
  journal={American journal of physical medicine & rehabilitation},
  year={2008},
  volume={87 10},
  pages={803-14}
}
OBJECTIVE To hypothesize that appropriate intermittent myocardial ischemia induced by exercise could safely promote coronary collateral formation in the ischemic area through the increased expression of vascular endothelial growth factor (VEGF) and its receptor fetal liver kinase-1 (Flk-1). DESIGN A balloon constrictor was surgically implanted in the first obtuse marginal coronary artery (OM1) of Guangxi BA-MA miniature pigs. The subjects were divided into three groups: sham-operated (SO… CONTINUE READING

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