Effect Comparison of Both Iron Chelators on Outcomes, Iron Deposit, and Iron Transporters After Intracerebral Hemorrhage in Rats

@article{Wang2015EffectCO,
  title={Effect Comparison of Both Iron Chelators on Outcomes, Iron Deposit, and Iron Transporters After Intracerebral Hemorrhage in Rats},
  author={Gaiqing Wang and Weimin Hu and Qingping Tang and Li Wang and Xin-gang Sun and Yanli Chen and Yongfeng Yin and Fang Zheng Xue and Zhitang Sun},
  journal={Molecular Neurobiology},
  year={2015},
  volume={53},
  pages={3576-3585}
}
  • Gaiqing Wang, Weimin Hu, +6 authors Zhitang Sun
  • Published 2015
  • Biology, Medicine
  • Molecular Neurobiology
  • Iron overload plays a key role in brain injury after intracerebral hemorrhage (ICH). We explored the roles of ferric iron chelator—deferiprone (DFP)—and ferrous iron chelator—clioquinol (CQ)—in ICH rats through the outcomes, iron deposits, reactive oxygen species (ROS), brain water content, and related iron transporters. One hundred eight Sprague-Dawley rats received intra-striatal infusions of 0.5 U of type IV collagenase to establish ICH models. The rats were randomly assigned to the sham… CONTINUE READING

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