Eff ect of rofl umilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy ( REACT ) : a multicentre randomised controlled trial

@inproceedings{Martinez2015EffEO,
  title={Eff ect of rofl umilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy ( REACT ) : a multicentre randomised controlled trial},
  author={Fernando J Martinez and Peter Michael Anthony Calverley and U M Goehring and Manja Brose and Leonardo Maria Fabbri and Klaus Friedrich Rabe},
  year={2015}
}
Background Rofl umilast reduces exacerbations in patients with severe chronic obstructive pulmonary disease. Its eff ect in patients using fi xed combinations of inhaled corticosteroids and longacting β2 agonists is unknown. We postulated that rofl umilast would reduce exacerbations in patients with severe chronic obstructive pulmonary disease at risk for exacerbations, even in combination with inhaled corticosteroid and longacting β2 agonist treatment. 

References

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Effi cacy of rofl umilast in the COPD frequent exacerbator phenotype

JA Wedzicha, KF Rabe, FJ Martinez
Chest • 2013

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