Eff ect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children : two open-label , randomised controlled trials

@inproceedings{Prymula2009EffEO,
  title={Eff ect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children : two open-label , randomised controlled trials},
  author={Roman Prymula and Claire-Anne Siegrist and Roman Chlibek and Helena Zemlickova and Marie Vackov{\'a} and Jan Smetana and Eva Kaliskova},
  year={2009}
}
Methods In two consecutive (primary and booster) randomised, controlled, open-label vaccination studies, 459 healthy infants were enrolled from ten centres in the Czech Republic. Infants were randomly assigned with a computergenerated randomisation list to receive three prophylactic paracetamol doses every 6–8 h in the fi rst 24 h (n=226) or no prophylactic paracetamol (n=233) after each vaccination with a ten-valent pneumococcal non-typeable Haemophilus infl uenzae protein D-conjugate vaccine… CONTINUE READING

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