Efavirenz plasma concentrations in HIV-infected patients: inter- and intraindividual variability and clinical effects.

@article{Sthle2004EfavirenzPC,
  title={Efavirenz plasma concentrations in HIV-infected patients: inter- and intraindividual variability and clinical effects.},
  author={Lars St{\aa}hle and Lars Moberg and J O Svensson and Anders S{\"o}nnerborg},
  journal={Therapeutic drug monitoring},
  year={2004},
  volume={26 3},
  pages={267-70}
}
Efavirenz is a drug subject to extensive metabolism, mainly by the cytochrome P-450 isoenzyme CYP2B6, known to exhibit extensive interindividual variability. The aim of the present study was 2-fold: to investigate the relationship between plasma concentration and clinical effects of efavirenz and to investigate the extent of the inter- and intraindividual variability of the plasma concentration measurements. From an open clinic, 68 HIV-positive patients on efavirenz-containing treatment were… CONTINUE READING

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