Efavirenz loaded nanostructured lipid carrier engineered for brain targeting through intranasal route: In-vivo pharmacokinetic and toxicity study.

@article{Pokharkar2017EfavirenzLN,
  title={Efavirenz loaded nanostructured lipid carrier engineered for brain targeting through intranasal route: In-vivo pharmacokinetic and toxicity study.},
  author={Varsha B Pokharkar and Arpana Patil-Gadhe and Piergiorgio Palla},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2017},
  volume={94},
  pages={
          150-164
        }
}
Intranasal delivery is a potential platform that can be employed in targeting the antiretrovirals (ARVs) to reach HIV that harbors in the central nervous system. The objective of the study was to develop an optimized efavirenz (EFV) loaded nanostructured lipid carrier (ENLC) and deliver it through intranasal route for brain targeting. Factorial design (23) was used to identify the key formulation variables influencing particle size and percent drug encapsulation of efavirenz in the NLC… CONTINUE READING

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