Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.

@article{Bumpus2011EfavirenzA8,
  title={Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes.},
  author={Namandj{\'e} N Bumpus},
  journal={Toxicology and applied pharmacology},
  year={2011},
  volume={257 2},
  pages={227-34}
}
Chronic use of efavirenz (EFV) has been linked to incidences of hepatotoxicity in patients receiving EFV to treat HIV-1. While recent studies have demonstrated that EFV stimulates hepatic cell death a role for the metabolites of efavirenz in this process has yet to be examined. In the present study, incubation of primary human hepatocytes with synthetic 8… CONTINUE READING