Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells

@inproceedings{Hecht2015EfavirenzHT,
  title={Efavirenz Has the Highest Anti-Proliferative Effect of Non-Nucleoside Reverse Transcriptase Inhibitors against Pancreatic Cancer Cells},
  author={Markus Hecht and Sonja Erber and Thomas Harrer and Hartwig H F Klinker and Thomas Roth and Hans Parsch and N. Fiebig and Rainer Fietkau and Luitpold V Distel and Luis Men{\'e}ndez-Arias},
  booktitle={PloS one},
  year={2015}
}
BACKGROUND Cancer prevention and therapy in HIV-1-infected patients will play an important role in future. The non-nucleoside reverse transcriptase inhibitors (NNRTI) Efavirenz and Nevirapine are cytotoxic against cancer cells in vitro. As other NNRTIs have not been studied so far, all clinically used NNRTIs were tested and the in vitro toxic concentrations were compared to drug levels in patients to predict possible anti-cancer effects in vivo. METHODS Cytotoxicity was studied by Annexin-V… CONTINUE READING

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