Ef ® cient RNA 2 ¢ - O - methylation requires juxtaposed and symmetrically assembled archaeal box C

Abstract

Box C/D ribonucleoprotein (RNP) complexes direct the nucleotide-speci®c 2¢-O-methylation of ribonucleotide sugars in target RNAs. In vitro assembly of an archaeal box C/D sRNP using recombinant core proteins L7, Nop56/58 and ®brillarin has yielded an RNA:protein enzyme that guides methylation from both the terminal box C/D core and internal C¢/D¢ RNP… (More)

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@inproceedings{JTranEfC, title={Ef ® cient RNA 2 ¢ - O - methylation requires juxtaposed and symmetrically assembled archaeal box C}, author={Elizabeth J.Tran and Xinxin Zhang and E. Stuart Maxwell} }