Edward B Lewis (1918–2004)

@article{Mishra2007EdwardBL,
  title={Edward B Lewis (1918–2004)},
  author={Rakesh K. Mishra},
  journal={Journal of Biosciences},
  year={2007},
  volume={29},
  pages={231-233}
}
E B Lewis died of cancer at the age of 86 on July 21 2004. A Caltech faculty member since 1946, Lewis spent his life working on the genetics of the fruit fly. In 1995, he shared the Nobel Prize in Physiology or Medicine for his contributions to our understanding of the bithorax complex (BX-C), a cluster of genes that regulate the identity of body segments in the posterior half of the thorax and abdomen of Drosophila melanogaster. Lewis graduated with a B.Sc. degree in Biostatistics from… Expand
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References

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E. B. Lewis and the bithorax complex: part I.
TLDR
The bithorax complex (BX-C), a gene cluster that controls the identities of body segments in the abdomen and posterior thorax of Drosophila, is described. Expand
E. B. Lewis and the bithorax complex: part II. From cis-trans test to the genetic control of development.
TLDR
As discussed in Part I of this Perspectives, E. B. Lewis found a series of five bithorax complex “pseudoalleles” separable by recombination and by function, with the map order: bx Cbx Ubx bxd pbx . Expand
A gene complex controlling segmentation in Drosophila
TLDR
The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element. Expand