Edoxaban versus warfarin in patients with atrial fibrillation.

@article{Giugliano2013EdoxabanVW,
  title={Edoxaban versus warfarin in patients with atrial fibrillation.},
  author={Robert P Giugliano and Christian Thomas Ruff and Eugene Braunwald and Sabina A. Murphy and Stephen D. Wiviott and Jonathan L. Halperin and Albert L. Waldo and Michael Ezekowitz and Jeffrey I Weitz and Jindrich Spinar and Witold Ruźyllo and Mikhail Ruda and Yukihiro Koretsune and Joshua M Betcher and Minggao Shi and Laura T Grip and Shirali P Patel and Indravadan V. Patel and James J. Hanyok and Michele Mercuri and Elliott Marshall Antman},
  journal={The New England journal of medicine},
  year={2013},
  volume={369 22},
  pages={2093-104}
}
BACKGROUND Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic… CONTINUE READING
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