Editorial to "Disturbances of cardiac wavelength and repolarization precede torsade de pointes and ventricular fibrillation in langendorff perfused rabbit hearts" by Luc Hondeghem: It is difficult to make predictions, especially about the future∗: Thoughts about forecasting cardiotoxicity of pharmacological interventions.

Abstract

Reliable preclinical safety testing of new compounds in general, and assessment of potential pro-arrhythmic properties in particular, are of the utmost importance yet loaded with challenges. To date no single electrical surrogate parameter in patients, and no single cellular, tissue or whole animal model, including computer simulations, enables reliable… (More)
DOI: 10.1016/j.pbiomolbio.2016.04.001

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