Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits

@article{Hewitt2012EditorialPO,
  title={Editorial Policy on Candidate Gene Association and Candidate Gene-by-Environment Interaction Studies of Complex Traits},
  author={John K. Hewitt},
  journal={Behavior Genetics},
  year={2012},
  volume={42},
  pages={1-2}
}
  • J. Hewitt
  • Published 2012
  • Medicine, Psychology
  • Behavior Genetics
The literature on candidate gene associations is full of reports that have not stood up to rigorous replication. This is the case both for straightforward main effects and for candidate gene-by-environment interactions (Duncan and Keller 2011). As a result, the psychiatric and behavior genetics literature has become confusing and it now seems likely that many of the published findings of the last decade are wrong or misleading and have not contributed to real advances in knowledge. The reasons… 
Candidate Gene–Environment Interaction Research
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Gene-by-environment interaction studies in psychiatry have typically been conducted using a candidate G×E (cG×E) approach, analogous to the candidate gene association approach used to test genetic main effects, yet cG–E findings remain controversial.
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The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct or analysis.
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Behav Genet
  • Behav Genet
  • 2012