Editorial: One Small Step for Metaplasia, but One Giant Leap for Biomarkers Is Needed

@article{Nicholson2009EditorialOS,
  title={Editorial: One Small Step for Metaplasia, but One Giant Leap for Biomarkers Is Needed},
  author={Anna Nicholson and Janusz Jankowski},
  journal={The American Journal of Gastroenterology},
  year={2009},
  volume={104},
  pages={2681-2683}
}
There are 5 to 6 levels of biomarker validation. Those for Barrett's esophagus are currently at level 3, despite small prospective studies. What is ideally required is a very large prospective assessment of biopsies in large cohorts, such as the ASPirin Esomeprazole Chemoprevention Trial (AspECT) and Barrett's Oesophagus Surveillance Study (BOSS) trials, so that unbiased and random selection of cases can be subjected to rigorous pathology and biomarker assessment (level 4). Only then can the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Aneuploidy and overexpression of Ki 67 and p 53 as markers for neoplastic progression in Barrett esophagus : a case control study

  • M Sikkema
  • Am J Gastroenterol
  • 2009

Biomarkers in gastroenterology : between hope and hype comes histopathology

  • JA Jankowski, RD Odze
  • Am J Gastroenterol
  • 2009

Similar Papers

Loading similar papers…