Editorial: Is it time for epigenetics in osteoarthritis?

  title={Editorial: Is it time for epigenetics in osteoarthritis?},
  author={Francisco J Blanco and Ignacio Rego-P{\'e}rez},
  journal={Arthritis & rheumatology},
  volume={66 9},
The pathogenesis of osteoarthritis (OA) involves cartilage degradation, synovial inflammation, subchondral bone sclerosis, degeneration of ligaments and meniscus, and hypertrophy of the joint capsule. There can also be changes in the periarticular muscles, nerves, bursa, and local fat pads that may contribute to OA. The manifestation of pathologic changes in all joint tissues defines OA as a disease of the “whole” joint as an organ, resulting in organ dysfunction or joint failure (1). OA is a… CONTINUE READING
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