Editorial: Hematopoietic stem cell theory in relation to possible lymphoblastic conversion of chronic myeloid leukemia.


By Dane R. Boggs C URRENT EVIDENCE SUGGESTS that chronic myeloid leukemia (CML) must be considered a clonal disease of a pluripotent hematopoietic stem cell compartment. The Philadelphia chromosome (Ph’ ) abnormality (translocation of a portion of the lOng arms of chromosome 22 onto chromosome 91) is found not only in neutro hil precursors, but in… (More)


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