Editorial: Gin tonic revisited

  title={Editorial: Gin tonic revisited},
  author={Christian G. Meyer and Florian Marks and Jürgen May},
  journal={Tropical Medicine \& International Health},
keywords antimalarial therapy, quinine, Cinchona barkSunset in the tropics. On the verandah: lounging Europeanexpats, buzzing mosquitoes, peak biting time. Once settledand seeking comfort and consolation, dawdling the hoursaway with generous gin & tonics, talks and tales soon turnto malaria. One has to drink gin tonic in the diaspora. Itkeeps away malaria and, with a twist of lime, even preventsscurvy. It is good for health.Stay cool and hark back to the febrifugal qualities oftonic water. It… 

Cinchona Bark For The Treatment Of Covid-19 Pnemonia: A Modern Review Of The Potential Anti-Viral Therapuetic Applications Of An Old Treatment

The existing evidence and evolving breakthrough CQ efficacy findings in China, shadowed by CQ shortage, highlight a need for modern and timely investigation of CB as cost-effective alternative COVID-19 pneumonia monotherapy.

Pharmacological Advances of Chloroquine and Hydroxychloroquine: From Antimalarials to Investigative Therapies in COVID-19

The medicinal history and pharmacological activities of chloroquine and hydroxychloroquine, derivatives of natural alkaloid quinine, and therapeutic potential in the emerging viral infection COVID-19 are discussed.

Binding behaviour and solubilisation of p-sulfonatocalixarenes to cinchona alkaloids

In this study, we investigated the binding behaviours of three water-soluble p-sulfonatocalixarenes with four cinchona alkaloids in aqueous and phosphate buffer solutions (pH 7.2 and 2.0). The

Cinchona Alkaloids Tethered on Porous Silica as Enantioselective Heterogeneous Catalysts

Cinchonidine, a naturally occurring cinchona alkaloid, was tethered to a high-surface-area silica substrate in order to create a new solid chiral catalyst. Two synthetic routes were explored for this

Conceptual and design essentials for evaluating mechanisms of change.

  • M. Nock
  • Psychology, Medicine
    Alcoholism, clinical and experimental research
  • 2007
Conceptualizing and conducting studies that test mechanisms of change requires substantial modifications to traditional research designs, but doing so will significantly enhance scientific understanding as well as the efficiency and effectiveness of clinical interventions.

Investigation of Molecular Interactions in Cytoskeletal Systems with Holographic Optical Tweezers

HOT was employed to create extended force sensor arrays, consisting of multiple trapped particles that were controlled and probed individually, and the second step of sporozoite adhesion sequence was found to be significantly dependend on actin and a specific transmembrane protein named TRAP.



Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: the importance of unbound quinine concentration.

Clinical pharmacology and malaria.

The role of clinical pharmacology in improving the prevention and treatment of malaria and the role of the pharmacologist and the chemist in designing out drug toxicity lends hope for producing a new generation of antimalarial drugs.

Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.

The validated LC/MS assay has proved to be appropriate for the isolation, separation, screening, identification and quantification of various neuroleptics in plasma for clinical toxicology and therapeutic drug monitoring purposes.

Quinine Pharmacokinetic-Pharmacodynamic Relationships in Uncomplicated Falciparum Malaria

The relationships between the pharmacokinetic properties of quinine during a 7-day treatment course and the therapeutic response were studied in 30 adult patients with uncomplicated falciparum malaria monitored for ≥28 days, and modeling of these data suggested an average minimum parasiticidal concentration of qu inine in plasma of 3.4 μg/ml.

Florian Marks and Jü rgen May (corresponding author), Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine

  • Bernhard Nocht Str