Editorial: 100 years of epidemic meningitis in West Africa – has anything changed?

@article{Greenwood2006Editorial1Y,
  title={Editorial: 100 years of epidemic meningitis in West Africa – has anything changed?},
  author={Brian Greenwood},
  journal={Tropical Medicine \& International Health},
  year={2006},
  volume={11}
}
  • B. Greenwood
  • Published 2006
  • Medicine
  • Tropical Medicine & International Health
Invasive meningococcal infection is probably a relatively new disease. The first recorded outbreak occurred in Geneva in 1805 (Vieusseux 1806). The following year, typical cases of meningococcal meningitis (cerebro-spinal meningitis) were seen in New England (Danielson &Mann 1806) and epidemics occurred across Europe and North America throughout the nineteenth century. In 1840, the first outbreak in Africa was reported among French troops based in Algiers (Chalmers & O’Farrell 1916) and during… Expand

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References

SHOWING 1-10 OF 43 REFERENCES
Manson Lecture. Meningococcal meningitis in Africa.
  • B. Greenwood
  • Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 1999
TLDR
In the medium term, the best prospect for the control of meningococcal meningitis in Africa lies in the recent development of polysaccharide-protein conjugate vaccines which, unlike poly Saccharide vaccines, are immunogenic in the very young, induce immunological memory and are likely to give long-lasting protection. Expand
Epidemic group C meningococcal meningitis in Upper Volta, 1979.
TLDR
Concern that the current increase in activity may presage more wide-spread disease in the next dry season of meningococcal meningitis in the sub-Saharan region. Expand
Emergency vaccination against epidemic meningitis in Ghana: implications for the control of meningococcal disease in West Africa
BACKGROUND Recurrent epidemics of meningococcal disease have been reported throughout the African meningitis belt since description of the disease in 1912. Meningooccal polysaccharide vaccines canExpand
MENINGOCOCCAL DISEASE AND SEASON IN SUB-SAHARAN AFRICA
TLDR
It is suggested that changes in the ratio of clinical to subclinical cases of infection are more important thanChanges in the frequency of transmission in producing seasonal variations in the incidence of meningococcal disease. Expand
Chronicle of an outbreak foretold: meningococcal meningitis W135 in Burkina Faso.
TLDR
Strategies to react to a future African epidemic of W135 meningococcal meningitis with a sufficient and affordable supply of vaccine must be put into place now. Expand
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana.
TLDR
The occurrence of serogroup X outbreaks argues for the inclusion of this serogroups into a multivalent conjugate vaccine against N. meningitidis, and three closely related clusters with distinct patterns of spread were identified among the Ghanian isolates. Expand
An outbreak of serotype 1 Streptococcus pneumoniae meningitis in northern Ghana with features that are characteristic of Neisseria meningitidis meningitis epidemics.
TLDR
The results suggest that this lineage of pneumococcal meningitis might have the potential to cause an epidemic, and mass vaccination with a less complex conjugate vaccine that targets hypervirulent serotypes should be considered. Expand
Meningitis caused by a serogroup W135 clone of the ET‐37 complex of Neisseria meningitidis in West Africa
TLDR
The findings of this study indicate that outbreaks of meningococcal meningitis in Africa can be associated with serogroup W135 infections and that serogroupsing is essential before vaccination campaigns are started. Expand
An epidemic of meningococcal infection at Zaria, Northern Nigeria. 2. The changing clinical pattern.
TLDR
It is suggested that the virulence of the causative group A meningococcus declined as the epidemic progressed. Expand
Where is the meningitis belt? Defining an area at risk of epidemic meningitis in Africa.
TLDR
The cumulative pan-continental analysis provided evidence of an epidemic-susceptible area which extends beyond the region accepted as the Meningitis Belt and which, moreover, may be partially determined by the physical environment, as shown by a striking correspondence to the 300-1100-mm mean annual rainfall isohyets. Expand
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