Editing of GluR2 RNA in the gerbil hippocampus after global cerebral ischemia.

  title={Editing of GluR2 RNA in the gerbil hippocampus after global cerebral ischemia.},
  author={Armin Rump and Clemens J Sommer and Peter Gass and Sylvain Bele and Dieane Meissner and Marika Kiessling},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={16 6},
Postischemic delayed neuronal death (DND) in CA1 of the gerbil hippocampus is thought to be caused by an abnormal increase of Ca2+ influx into the cell, mediated by excessive activation of glutamate receptors. One subtype of glutamate receptors, the AMPA receptor, is not permeable to calcium ions as long as an edited form of its GluR2 subunit is present. It is possible that global ischemia interferes with the posttranscriptional editing of the GluR2 mRNA and thus leads to calcium influx via the… CONTINUE READING
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A (1992) Switch in glutamate receptor subunit gene expression in CA I subfield of hippocampus following global ischemia in rats

  • DE Pellegrini Giampietro, RS Zukin, MV Bennett, S Cho, W Pulsinelli
  • 1992

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