Editing and investigating genomes with TALE and CRISPR/Cas systems: genome engineering across species using TALENs.

Abstract

http://dx.doi.org/10.1016/j.ymeth.2014.08.012 1046-2023/ 2014 Elsevier Inc. All rights reserved. Genome engineering in cells and organisms to create targeted mutants is a key technology for genetics and biotechnology. The ascent of the mouse as genetic model organism is based on the development of gene targeting technology in embryonic stem (ES) cells that… (More)
DOI: 10.1016/j.ymeth.2014.08.012

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