Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.

@article{Liu2000Edg1TG,
  title={Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.},
  author={Y Liu and Ryuichi Wada and Tadashi Yamashita and Yan Mi and Chuxia Deng and John Peyton Hobson and Hans M. Rosenfeldt and Victor E. Nava and Sungsuk Chae and M. J. Lee and C H Liu and Timothy Hla and Sarah Spiegel and Richard L. Proia},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 8},
  pages={
          951-61
        }
}
  • Y. Liu, R. Wada, R. Proia
  • Published 15 October 2000
  • Biology
  • The Journal of clinical investigation
Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high concentrations in platelets and blood, stimulates members of the endothelial differentiation gene (Edg) family of G protein-coupled receptors and triggers diverse effects, including cell growth, survival, migration, and morphogenesis. To determine the in vivo functions of the SPP/Edg signaling pathway, we disrupted the Edg1 gene in mice… 

Figures and Tables from this paper

Sphingosine 1-phosphate receptors.
  • T. Hla
  • Biology
    Prostaglandins & other lipid mediators
  • 2001
Sphingosine-1-phosphate: an emerging therapeutic target
TLDR
The biosynthesis, metabolism and potential functions of SPP in diverse diseases are examined in order to illuminate targets for the pharmaceutical and therapeutic manipulation ofSPP levels.
Role of the Sphingosine 1-Phosphate Receptor EDG-1 in Vascular Smooth Muscle Cell Proliferation and Migration
TLDR
Enhanced expression of EDG-1 in VSMCs dramatically stimulates both the proliferative and migratory responses to S1P, suggesting that activation of p70 S6 kinase is critical in EDg-1/Gi–mediated cell proliferation.
Sphingosine 1-phosphate as a therapeutic agent
TLDR
Radiation-induced oocyte loss in adult female mice, the event that drives premature ovarian failure and infertility in female cancer patients, was completely prevented by in vivotherapy with S1P, the ligand for five G protein-coupled receptors.
Mouse SPNS2 Functions as a Sphingosine-1-Phosphate Transporter in Vascular Endothelial Cells
TLDR
It is shown that SPNS2 functions as an S1P transporter in vascular endothelial cells but not in erythrocytes and platelets and is a key determinant of lymphocyte egress from the thymus.
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development
TLDR
It is demonstrated that LRP1 modulates Gi-dependent sphingosine-1-phosphate (S1P) signaling and integrates S1P and PDGF-BB signaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain, and reveals an unexpected link between lipoprotein receptor and sphingolipid signaling.
Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility
TLDR
A role for receptor cross-communication in which activation of a GPCR by a receptor tyrosine kinase is critical for cell motility is revealed.
G protein-coupled sphingosine-1-phosphate receptors: potential molecular targets for angiogenic and anti-angiogenic therapies
TLDR
The findings provide the molecular basis for S1P receptor subtype-selective targeting strategies aiming at angiogenic therapy for occlusive peripheral arterial diseases, and anti-angiogenic andAnti-tumor therapies against cancer.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 63 REFERENCES
Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1.
TLDR
Overexpression of EDG-1 induced exaggerated cell-cell aggregation, enhanced expression of cadherins, and formation of well-developed adherens junctions in a manner dependent on SPP and the small guanine nucleotide binding protein Rho.
Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate
  • E. Goetzl, S. An
  • Biology, Chemistry
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1998
TLDR
Many of the cellular effects of LPA and S1P are attributable to modifications in the content and/or activity of a major functional protein, including induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis.
Sphingosine 1-Phosphate Stimulates Cell Migration through a Gi-coupled Cell Surface Receptor
TLDR
The results suggest that SPP may play a role in angiogenesis through binding to endothelial cell Gi-coupled SPP receptors and checkerboard analysis indicated that sphingosine 1-phosphate stimulates both chemotaxis and chemokinesis.
A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development
TLDR
A new role for lysosphingolipids in regulating cell migration during vertebrate development is revealed and the first molecular clues into the fusion of the bilateral heart primordia during organogenesis of the heart are provided.
Differential Pharmacological Properties and Signal Transduction of the Sphingosine 1-Phosphate Receptors EDG-1, EDG-3, and EDG-5*
TLDR
It is concluded that the three SPP receptors signal differentially by coupling to different G-proteins, which suggests that this property may be exploited to synthesize receptor subtype-specific antagonists.
Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells.
TLDR
Results indicate that S1P induces angiogenesis predominantly via G(i) protein-coupled receptors in endothelial cells and suggest that S 1P may act as an important modulator of platelet-induced angiogenicity.
The mouse gene for the inducible G-protein-coupled receptor edg-1.
Edg-1, an immediate-early gene induced during the in vitro differentiation of human endothelial cells, encodes a G-protein-coupled receptor (GPR) that signals via the G(i)/mitogen-activated protein
Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration.
TLDR
Results indicate that S1P and, for some cells, LPA stimulate migration of endothelial cells through a mechanism that likely requires a balance between G(i) and Rho signaling to achieve the cytoskeletal remodeling necessary for cell migration.
Differential Coupling of the Sphingosine 1-Phosphate Receptors Edg-1, Edg-3, and H218/Edg-5 to the Gi, Gq, and G12 Families of Heterotrimeric G Proteins*
TLDR
These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling.
...
1
2
3
4
5
...